-----BEGIN PRIVACY-ENHANCED MESSAGE----- Proc-Type: 2001,MIC-CLEAR Originator-Name: webmaster@www.sec.gov Originator-Key-Asymmetric: MFgwCgYEVQgBAQICAf8DSgAwRwJAW2sNKK9AVtBzYZmr6aGjlWyK3XmZv3dTINen TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB MIC-Info: RSA-MD5,RSA, WUg8PEbQhvy+TcDx7Wum1uOT2BEqPKNo3Sym8vPnBuNq1hON45+OscQ0MtTQv4i4 ocekbFM4iibQ1ASg/p+j/Q== 0001178913-10-001779.txt : 20100712 0001178913-10-001779.hdr.sgml : 20100712 20100712060320 ACCESSION NUMBER: 0001178913-10-001779 CONFORMED SUBMISSION TYPE: SC 13G/A PUBLIC DOCUMENT COUNT: 3 FILED AS OF DATE: 20100712 DATE AS OF CHANGE: 20100712 GROUP MEMBERS: DORON BREEN GROUP MEMBERS: ISRAEL MOR GROUP MEMBERS: M. ARKIN (1999) LTD. GROUP MEMBERS: RON SENATOR GROUP MEMBERS: SPHERA FUNDS MANAGEMENT LTD. FILED BY: COMPANY DATA: COMPANY CONFORMED NAME: Arkin Moshe CENTRAL INDEX KEY: 0001321178 FILING VALUES: FORM TYPE: SC 13G/A MAIL ADDRESS: STREET 1: C/O PERRIGO, 515 EASTERN AVENUE CITY: ALLEGAN STATE: MI ZIP: 49010 SUBJECT COMPANY: COMPANY DATA: COMPANY CONFORMED NAME: Orexigen Therapeutics, Inc. CENTRAL INDEX KEY: 0001382911 STANDARD INDUSTRIAL CLASSIFICATION: PHARMACEUTICAL PREPARATIONS [2834] IRS NUMBER: 651178822 STATE OF INCORPORATION: DE FISCAL YEAR END: 1231 FILING VALUES: FORM TYPE: SC 13G/A SEC ACT: 1934 Act SEC FILE NUMBER: 005-83422 FILM NUMBER: 10947180 BUSINESS ADDRESS: STREET 1: 3344 N. TORREY PINES CT. STREET 2: SUITE 200 CITY: LA JOLLA STATE: CA ZIP: 92037 BUSINESS PHONE: (858) 875-8600 MAIL ADDRESS: STREET 1: 3344 N. TORREY PINES CT. STREET 2: SUITE 200 CITY: LA JOLLA STATE: CA ZIP: 92037 SC 13G/A 1 zk1008513.txt UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G (RULE 13D-102) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO RULES 13D-1(B), (C), AND (D) AND AMENDMENTS THERETO FILED PURSUANT TO RULE 13D-2 UNDER THE SECURITIES EXCHANGE ACT OF 1934 (AMENDMENT NO. 2 )* (1) Orexigen Therapeutics, Inc. ---------------------------------------- (NAME OF ISSUER) Common Stock ---------------------------------------- (TITLE OF CLASS OF SECURITIES) 686164104 ---------------------------------------- (CUSIP NUMBER) June 8, 2010 ---------------------------------------- (DATE OF EVENT WHICH REQUIRES FILING OF THIS STATEMENT) Check the appropriate box to designate the rule pursuant to which this Schedule is filed: [_] Rule 13d-1(b) [X] Rule 13d-1(c) [_] Rule 13d-1(d) *The remainder of this cover page shall be filled out for a reporting person's initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover page. The information required in the remainder of this cover page shall not be deemed to be "filed" for the purpose of Section 18 of the SECURITIES EXCHANGE ACT of 1934 ("Act") or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes). (1) This Amendment No. 2 to Schedule 13G corrects Amendment No. 1 to Schedule 13G filed June 17, 2010 ("Amendment No. 1") and replaces Amendment No. 1 in its entirety. All figures contained herein are as of June 8, 2010 unless otherwise indicated. - -------------------------------- -------------------------------- CUSIP NO. 686164104 13G PAGE 2 OF 14 PAGES - -------------------------------- -------------------------------- - -------------------------------------------------------------------------------- 1 NAME OF REPORTING PERSONS Moshe Arkin - -------------------------------------------------------------------------------- 2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See instructions) (a) [_] (b) [X] - -------------------------------------------------------------------------------- 3 SEC USE ONLY - -------------------------------------------------------------------------------- 4 CITIZENSHIP OR PLACE OF ORGANIZATION Israel - -------------------------------------------------------------------------------- 5 SOLE VOTING POWER 4,277,766 NUMBER OF ---------------------------------------------------------- SHARES 6 SHARED VOTING POWER BENEFICIALLY 591,877 OWNED BY ---------------------------------------------------------- EACH 7 SOLE DISPOSITIVE POWER REPORTING 4,277,766 PERSON WITH ---------------------------------------------------------- 8 SHARED DISPOSITIVE POWER 591,877 - -------------------------------------------------------------------------------- 9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 4,869,643 (1) - -------------------------------------------------------------------------------- 10 CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (See instructions) [_] - -------------------------------------------------------------------------------- 11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9 10.31% (2) - -------------------------------------------------------------------------------- 12 TYPE OF REPORTING PERSON (See instructions) IN - -------------------------------------------------------------------------------- (1) Although not included in this Schedule 13G, 104,700 shares of Common Stock of Orexigen Therapeutics, Inc. are currently held by a mutual fund called Menora Mivtachim 50% Equities (the "Menora Mutual Fund"), which is managed by Menora Mivtachim Mutual Funds Ltd. Mr. Arkin owns 99.58% of the shares in the Menorah Mutual Fund. (2) Based on 47,216,779 shares of common stock outstanding as of May 7, 2010 (as reported in the Issuer's Form 10-Q filed with the Securities and Exchange Commission ("SEC") on May 10, 2010). 2 - -------------------------------- -------------------------------- CUSIP NO. 686164104 13G PAGE 3 OF 14 PAGES - -------------------------------- -------------------------------- - -------------------------------------------------------------------------------- 1 NAME OF REPORTING PERSONS M. Arkin (1999) Ltd. - -------------------------------------------------------------------------------- 2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See instructions) (a) [_] (b) [X] - -------------------------------------------------------------------------------- 3 SEC USE ONLY - -------------------------------------------------------------------------------- 4 CITIZENSHIP OR PLACE OF ORGANIZATION Israel - -------------------------------------------------------------------------------- 5 SOLE VOTING POWER - NUMBER OF --------------------------------------------------------- SHARES 6 SHARED VOTING POWER BENEFICIALLY 591,877 OWNED BY --------------------------------------------------------- EACH 7 SOLE DISPOSITIVE POWER REPORTING - PERSON WITH --------------------------------------------------------- 8 SHARED DISPOSITIVE POWER 591,877 - -------------------------------------------------------------------------------- 9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 591,877 - -------------------------------------------------------------------------------- 10 CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (See instructions) [_] - -------------------------------------------------------------------------------- 11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9 1.25% (1) - -------------------------------------------------------------------------------- 12 TYPE OF REPORTING PERSON (See instructions) CO - -------------------------------------------------------------------------------- (1) Based on 47,216,779 shares of common stock outstanding as of May 7, 2010 (as reported in the Issuer's Form 10-Q filed with the SEC on May 10, 2010). 3 - -------------------------------- -------------------------------- CUSIP NO. 686164104 13G PAGE 4 OF 14 PAGES - -------------------------------- -------------------------------- - -------------------------------------------------------------------------------- 1 NAME OF REPORTING PERSONS Sphera Funds Management Ltd. - -------------------------------------------------------------------------------- 2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See instructions) (a) [_] (b) [X] - -------------------------------------------------------------------------------- 3 SEC USE ONLY - -------------------------------------------------------------------------------- 4 CITIZENSHIP OR PLACE OF ORGANIZATION Israel - -------------------------------------------------------------------------------- 5 SOLE VOTING POWER - NUMBER OF ---------------------------------------------------------- SHARES 6 SHARED VOTING POWER BENEFICIALLY 4,869,643 (1) OWNED BY ---------------------------------------------------------- EACH 7 SOLE DISPOSITIVE POWER REPORTING - PERSON WITH ---------------------------------------------------------- 8 SHARED DISPOSITIVE POWER 4,869,643 (1) - -------------------------------------------------------------------------------- 9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 4,869,643 (1) - -------------------------------------------------------------------------------- 10 CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (See instructions) [_] - -------------------------------------------------------------------------------- 11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9 10.31% (1) (2) - -------------------------------------------------------------------------------- 12 TYPE OF REPORTING PERSON (See instructions) CO - -------------------------------------------------------------------------------- (1) This figure includes 4,277,766 shares beneficially owned directly by Moshe Arkin (regarding which the cover page for Mr. Arkin indicates that he has sole voting and dispositive power) since the reporting persons named in this Schedule 13G may be deemed to constitute a "group" for purposes of Section 13(d) of the Exchange Act. Sphera Funds Management Ltd. disclaims existence of a group and beneficial ownership of such shares. (2) Based on 47,216,779 shares of common stock outstanding as of May 7, 2010 (as reported in the Issuer's Form 10-Q filed with the SEC on May 10, 2010). 4 - -------------------------------- -------------------------------- CUSIP NO. 686164104 13G PAGE 5 OF 14 PAGES - -------------------------------- -------------------------------- - -------------------------------------------------------------------------------- 1 NAME OF REPORTING PERSONS Israel Mor - -------------------------------------------------------------------------------- 2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See instructions) (a) [_] (b) [X] - -------------------------------------------------------------------------------- 3 SEC USE ONLY - -------------------------------------------------------------------------------- 4 CITIZENSHIP OR PLACE OF ORGANIZATION Israel - -------------------------------------------------------------------------------- 5 SOLE VOTING POWER - NUMBER OF ---------------------------------------------------------- SHARES 6 SHARED VOTING POWER BENEFICIALLY 4,869,643 (1) OWNED BY ---------------------------------------------------------- EACH 7 SOLE DISPOSITIVE POWER REPORTING - PERSON WITH ---------------------------------------------------------- 8 SHARED DISPOSITIVE POWER 4,869,643 (1) - -------------------------------------------------------------------------------- 9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 4,869,643 (1) - -------------------------------------------------------------------------------- 10 CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (See instructions) [_] - -------------------------------------------------------------------------------- 11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9 10.31% (1) (2) - -------------------------------------------------------------------------------- 12 TYPE OF REPORTING PERSON (See instructions) IN - -------------------------------------------------------------------------------- (1) This figure includes 4,277,766 shares beneficially owned directly by Moshe Arkin (regarding which the cover page for Mr. Arkin indicates that he has sole voting and dispositive power) since the reporting persons named in this Schedule 13G may be deemed to constitute a "group" for purposes of Section 13(d) of the Exchange Act. Israel Mor disclaims existence of a group and beneficial ownership of such shares. (2) Based on 47,216,779 shares of common stock outstanding as of May 7, 2010 (as reported in the Issuer's Form 10-Q filed with the SEC on May 10, 2010). 5 - -------------------------------- -------------------------------- CUSIP NO. 686164104 13G PAGE 6 OF 14 PAGES - -------------------------------- -------------------------------- - -------------------------------------------------------------------------------- 1 NAME OF REPORTING PERSONS Doron Breen - -------------------------------------------------------------------------------- 2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See instructions) (a) [_] (b) [X] - -------------------------------------------------------------------------------- 3 SEC USE ONLY - -------------------------------------------------------------------------------- 4 CITIZENSHIP OR PLACE OF ORGANIZATION Israel and U.S. - -------------------------------------------------------------------------------- 5 SOLE VOTING POWER - NUMBER OF ---------------------------------------------------------- SHARES 6 SHARED VOTING POWER BENEFICIALLY 4,869,643 (1) OWNED BY ---------------------------------------------------------- EACH 7 SOLE DISPOSITIVE POWER REPORTING - PERSON WITH ---------------------------------------------------------- 8 SHARED DISPOSITIVE POWER 4,869,643 (1) - -------------------------------------------------------------------------------- 9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 4,869,643 (1) - -------------------------------------------------------------------------------- 10 CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (See instructions) [_] - -------------------------------------------------------------------------------- 11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9 10.31% (1) (2) - -------------------------------------------------------------------------------- 12 TYPE OF REPORTING PERSON (See instructions) IN - -------------------------------------------------------------------------------- (1) This figure includes 4,277,766 shares beneficially owned directly by Moshe Arkin (regarding which the cover page for Mr. Arkin indicates that he has sole voting and dispositive power) since the reporting persons named in this Schedule 13G may be deemed to constitute a "group" for purposes of Section 13(d) of the Exchange Act. Doron Breen disclaims existence of a group and beneficial ownership of such shares. (2) Based on 47,216,779 shares of common stock outstanding as of May 7, 2010 (as reported in the Issuer's Form 10-Q filed with the SEC on May 10, 2010). 6 - -------------------------------- -------------------------------- CUSIP NO. 686164104 13G PAGE 7 OF 14 PAGES - -------------------------------- -------------------------------- - -------------------------------------------------------------------------------- 1 NAME OF REPORTING PERSONS Ron Senator - -------------------------------------------------------------------------------- 2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See instructions) (a) [_] (b) [X] - -------------------------------------------------------------------------------- 3 SEC USE ONLY - -------------------------------------------------------------------------------- 4 CITIZENSHIP OR PLACE OF ORGANIZATION Israel and U.S. - -------------------------------------------------------------------------------- 5 SOLE VOTING POWER - NUMBER OF ---------------------------------------------------------- SHARES 6 SHARED VOTING POWER BENEFICIALLY 4,869,643 (1) OWNED BY ---------------------------------------------------------- EACH 7 SOLE DISPOSITIVE POWER REPORTING - PERSON WITH ---------------------------------------------------------- 8 SHARED DISPOSITIVE POWER 4,869,643 (1) - -------------------------------------------------------------------------------- 9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 4,869,643 (1) - -------------------------------------------------------------------------------- 10 CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (See instructions) [_] - -------------------------------------------------------------------------------- 11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9 10.31% (1) (2) - -------------------------------------------------------------------------------- 12 TYPE OF REPORTING PERSON (See instructions) IN - -------------------------------------------------------------------------------- (1) This figure includes 4,277,766 shares beneficially owned directly by Moshe Arkin (regarding which the cover page for Mr. Arkin indicates that he has sole voting and dispositive power) since the reporting persons named in this Schedule 13G may be deemed to constitute a "group" for purposes of Section 13(d) of the Exchange Act. Ron Senator disclaims existence of a group and beneficial ownership of such shares. (2) Based on 47,216,779 shares of common stock outstanding as of May 7, 2010 (as reported in the Issuer's Form 10-Q filed with the SEC on May 10, 2010). 7 ITEM 1. (a) NAME OF ISSUER: Orexigen Therapeutics, Inc. (b) ADDRESS OF ISSUER'S PRINCIPAL EXECUTIVE OFFICES: 3344 North Torrey Pines Court, Suite 200, La Jolla, CA ITEM 2. (a) NAME OF PERSON FILING: 1. Moshe Arkin 2. M. Arkin (1999) Ltd. 3. Sphera Funds Management Ltd. 4. Israel Mor 5. Doron Breen 6. Ron Senator A portion of the securities reported herein (591,877 shares, representing 1.35% of the shares of Common Stock outstanding) are beneficially owned by Sphera Global Healthcare Fund, which invests substantially all of its assets in Sphera Global Healthcare Master Fund. Sphera Global Healthcare Fund and Sphera Global Healthcare Master Fund have delegated all investment decision-making to Sphera Global Healthcare Management L.P. (the "Management Company"). The Management Company is managed, controlled, and operated by its general partner, Sphera Global Healthcare GP Ltd. (the "General Partner"), the shares of which are owned 50% by M. Arkin (1999) Ltd. (the "1999 Company") and 50% by Sphera Funds Management Ltd. ("SFML"). The 1999 Company, wholly-owned by Mr. Arkin, and SFML are each entitled to appoint two members to the board of directors of the General Partner (the "Board of Directors") and two members to the investment committee of the Management Company (the "Investment Committee"), which reviews all investment decisions by the Management Company and determines the investment guidelines and strategy to be implemented. No decision can be made by either the Board of Directors or the Investment Committee without the consent of both Mr. Arkin's designees and the designees of SFML (Sphera Global Healthcare Fund, Sphera Global Healthcare Master Fund, the Management Company, and the General Partner are referred to collectively in this Schedule 13G as "Healthcare Fund Entities"). In addition, 62.09% of the shares of SFML are owned by companies controlled or wholly-owned by the three founders of SFML, Israel Mor, Doron Breen, and Ron Senator, each of whom currently serves as a director of SFML. 8 (b) ADDRESS OF PRINCIPAL BUSINESS OFFICE: Moshe Arkin - 6 Hachoshlim St., Herzelia, Israel M. Arkin (1999) Ltd. - 6 Hachoshlim St., Herzelia, Israel Sphera Funds Management Ltd. - Platinum House, 21 Ha'arba'ah Street, Tel-Aviv, 64739 Israel Israel Mor - c/o Sphera Funds Management Ltd., Platinum House, 21 Ha'arba'ah Street, Tel-Aviv, 64739 Israel Doron Breen - c/o Sphera Funds Management Ltd., Platinum House, 21 Ha'arba'ah Street, Tel-Aviv, 64739 Israel Ron Senator - c/o Sphera Funds Management Ltd., Platinum House, 21 Ha'arba'ah Street, Tel-Aviv, 64739 Israel (c) CITIZENSHIP: Moshe Arkin - Israel M. Arkin (1999) Ltd. - Israel Sphera Funds Management Ltd. - Israel Israel Mor - Israel Doron Breen - Israel and U.S. Ron Senator - Israel and U.S. (d) TITLE OF CLASS OF SECURITIES: Common Stock (e) CUSIP NUMBER: 686164104 ITEM 3. N.A. ITEM 4. OWNERSHIP: (a) AMOUNT BENEFICIALLY OWNED: See row 9 of cover page of each reporting person. Except for the shares of Common Stock owned directly by Mr. Arkin, each entity named in this Schedule 13G and Mr. Arkin disclaims beneficial ownership of any such shares. Neither the filing of this Schedule 13G nor any of its contents shall be deemed to constitute an admission that any such entity or individual is the beneficial owner of the shares referred to herein for purposes of Section 13(d) of the Exchange Act or for any other purpose. 9 The entities named in this Schedule 13G and Mr. Arkin may be deemed to constitute a "group" for purposes of Section 13(d) of the Exchange Act. Neither the filing of this Schedule 13G nor any of its contents shall be deemed to constitute an admission that a group exists for purposes of Section 13(d) of the Exchange Act or for any other purpose, and each of the entities named in this Schedule 13G and Mr. Arkin disclaims the existence of any such group. (b) PERCENT OF CLASS: See row 11 of cover page of each reporting person (c) NUMBER OF SHARES AS TO WHICH SUCH PERSON HAS: (i) Sole power to vote or to direct the vote: See row 5 of cover page of each reporting person (ii) Shared power to vote or to direct the vote: See row 6 of cover page of each reporting person and note in Item 4(a) above (iii) Sole power to dispose or to direct the disposition of: See row 7 of cover page of each reporting person (iv) Shared power to dispose or to direct the disposition of: See row 8 of cover page of each reporting person and note in Item 4(a) above ITEM 5. OWNERSHIP OF FIVE PERCENT OR LESS OF A CLASS: N.A. N.A. ITEM 6. OWNERSHIP OF MORE THAN FIVE PERCENT ON BEHALF OF ANOTHER: N.A. ITEM 7. IDENTIFICATION AND CLASSIFICATION OF THE SUBSIDIARY WHICH ACQUIRED THE SECURITY BEING REPORTED ON BY THE PARENT HOLDING COMPANY OR CONTROL PERSON: N.A. ITEM 8. IDENTIFICATION AND CLASSIFICATION OF MEMBERS OF THE GROUP: N.A. ITEM 9. NOTICE OF DISSOLUTION OF GROUP: N.A. 10 ITEM 10. CERTIFICATION: By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect. 11 SIGNATURE After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct. July 12, 2010 MOSHE ARKIN /s/ Menachem Inbar ---------------------------- By: Menachem Inbar* Title: Attorney-in-fact M. ARKIN (1999) LTD. /s/ Menachem Inbar ---------------------------- By: Menachem Inbar** Title: Attorney-in-fact for Moshe Arkin, Chairman of M. Arkin (1999) Ltd. SPHERA FUNDS MANAGEMENT LTD. /s/ Ron Senator ---------------------------- By: Ron Senator*** Title: Director /s/ Doron Breen ---------------------------- By: Doron Breen*** Title: Director 12 /s/ Israel Mor ---------------------------- Israel Mor /s/ Doron Breen ---------------------------- Doron Breen /s/ Ron Senator ---------------------------- Ron Senator * Duly authorized under Special Power of Attorney appointing Menachem Inbar attorney-in-fact, dated February 9, 2010 by and on behalf of Moshe Arkin (incorporated herein by reference to Exhibit 2 to the Schedule 13G filed on February 9, 2010). ** Duly authorized under Special Power of Attorney appointing Menachem Inbar attorney-in-fact, dated February 9, 2010 by and on behalf of Moshe Arkin as Chairman of M. Arkin (1999) Ltd. (incorporated herein by reference to Exhibit 3 to the Schedule 13G filed on February 9, 2010). *** Duly authorized by Unanimous Written Consent of the Board of Directors of Sphera Funds Management Ltd. allowing Ron Senator, Doron Breen, and Israel Mor, any two of whom acting together, to bind Sphera Funds Management Ltd. for any and all matters, dated July 1, 2010, attached hereto as Exhibit 4. 13 EXHIBIT NO. DESCRIPTION Exhibit 1 Agreement of Joint Filing. Exhibit 2 Special Power of Attorney appointing Menachem Inbar attorney-in- fact, dated February 9, 2010 by and on behalf of Moshe Arkin (incorporated herein by reference to Exhibit 2 to the Schedule 13G filed on February 9, 2010). Exhibit 3 Special Power of Attorney appointing Menachem Inbar attorney-in-fact, dated February 9, 2010 by and on behalf of Moshe Arkin as Chairman of M. Arkin (1999) Ltd. (incorporated herein by reference to Exhibit 3 to the Schedule 13G filed on February 9, 2010). Exhibit 4 Unanimous Written Resolutions of the Directors of Sphera Funds Management Ltd. allowing Ron Senator, Doron Breen, and Israel Mor, any two of whom acting together, to bind Sphera Funds Management Ltd. for any and all matters, dated July 1, 2010. 14 EX-1 2 exhibit_1.txt EXHIBIT 1 JOINT FILING AGREEMENT By this Agreement, the undersigned agree that this Statement on Schedule 13G being filed on or about this date, and any subsequent amendments thereto filed by any of us, with respect to the securities of Orexigen Therapeutics, Inc. is being filed on behalf of each of us. July 12, 2010 MOSHE ARKIN /s/ Menachem Inbar ---------------------------- By: Menachem Inbar* Title: Attorney-in-fact M. ARKIN (1999) LTD. /s/ Menachem Inbar ---------------------------- By: Menachem Inbar** Title: Attorney-in-fact for Moshe Arkin, Chairman of M. Arkin (1999) Ltd. SPHERA FUNDS MANAGEMENT LTD. /s/ Ron Senator ---------------------------- By: Ron Senator*** Title: Director /s/ Doron Breen ---------------------------- By: Doron Breen*** Title: Director /s/ Israel Mor ---------------------------- Israel Mor /s/ Doron Breen ---------------------------- Doron Breen /s/ Ron Senator ---------------------------- Ron Senator * Duly authorized under Special Power of Attorney appointing Menachem Inbar attorney-in-fact, dated February 9, 2010 by and on behalf of Moshe Arkin (incorporated herein by reference to Exhibit 2 to the Schedule 13G filed on February 9, 2010). ** Duly authorized under Special Power of Attorney appointing Menachem Inbar attorney-in-fact, dated February 9, 2010 by and on behalf of Moshe Arkin as Chairman of M. Arkin (1999) Ltd. (incorporated herein by reference to Exhibit 3 to the Schedule 13G filed on February 9, 2010). *** Duly authorized by Unanimous Written Consent of the Board of Directors of Sphera Funds Management Ltd. allowing Ron Senator, Doron Breen, and Israel Mor, any two of whom acting together, to bind Sphera Funds Management Ltd. for any and all matters, dated July 1, 2010, attached hereto as Exhibit 4. 2 EX-4 3 exhibit_4.txt EXHIBIT 4 SPHERA FUNDS MANAGEMENT LTD. (the "COMPANY") UNANIMOUS WRITTEN RESOLUTIONS OF THE DIRECTORS OF THE COMPANY DATED 1ST JULY, 2010 The undersigned, comprising all the members of the Board of Directors of the Company, in lieu of meeting, pursuant to the Articles of Association of the Company and waiving any prior notice requirements, do hereby consent in writing as follows: It is hereby RESOLVED THAT: 1. The authorized signatories, on behalf and in the name of the Company, shall be divided into two groups as follows: GROUP 1 GROUP 2 Israel Mor (I.D. * * *) Itschak Shrem (I.D. * * *) Doron Breen (I.D. * * *) Neomi Elpeleg (I.D. * * *) Ron Senator (I.D. * * *) 2. The signature of (i) any two authorized signatories from Group 1 OR (ii) the signature of any ONE authorized signatory from Group 1, ALONG WITH the signature of any one authorized signatory from Group 2; along with the name of Partnership, shall bind the Company for all purposes whatsoever * * *. 3. Signatures transmitted via facsimile shall be acceptable for all Company purposes. 4. * * * 5. Any of the authorized signatories shall be authorized to sign all other documents necessary to give effect to the foregoing resolutions. 6. These resolutions terminate any previous resolutions of the Company in respect of the signature rights in the Company. IN WITNESS WHEREOF, it has been resolved as of the date appearing above. /S/ ITSCHAK SHREM /S/ EHUD GELBARD ----------------- ---------------- Itschak Shrem Ehud Gelbard Director Director /S/ DORON BREEN /S/ ISRAEL MOR --------------- -------------- Doron Breen Israel Mor Director Director /S/ RON SENATOR --------------- Ron Senator Director -----END PRIVACY-ENHANCED MESSAGE-----